Mechanism of disintegrant action of polacrilin potassium: Swelling or wicking?

The effect of particle size, pH of medium, and presence of lubricant on the swelling behaviour, water uptake properties and disintegrant performance of polacrilin potassium was examined. Particle size did not affect the bulk swelling of disintegrant particles when measured as settling volume, but in...

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Bibliographic Details
Main Authors: Mrudula Hemant Bele, Diliprao Vishramji Derle
Format: Article
Language:English
Published: Elsevier 2012-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383511001043