Pulmonary Hypertension in Obese Mice Is Accompanied by a Reduction in PPAR-γ Expression in Pulmonary Artery

Pulmonary Hypertension in Obese Mice Is Accompanied by a Reduction in PPAR-γ Expression in Pulmonary Artery

Obesity and insulin resistance (IR) are well-studied risk factors for systemic cardiovascular disease, but their impact on pulmonary hypertension (PH) is not well clarified. This study aims to investigate if diet-induced obesity induces PH and if peroxisome-proliferator-activated receptor (PPAR-γ) a...

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Bibliographic Details
Main Authors: Any Elisa de Souza Schmidt Gonçalves, Guilherme Zweig Rocha, Rodrigo Marin, Rafael Ludemann Camargo, Andrey dos Santos, Helison do Carmo, Dioze Guadagnini, Orlando Petrucci, Zenaide Providello Moysés, Vera Maria Cury Salemi, Alexandre Gabarra Oliveira, Mario José Abdalla Saad
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Endocrinology
Subjects:
obesity
insulin resistance
pioglitazone
PPAR-γ
high-fat (HF) diet
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.701994/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2021.701994/full

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