Challenges in diagnosis and management of neutropenia upon exposure to immune-checkpoint inhibitors: meta-analysis of a rare immune-related adverse side effect

Challenges in diagnosis and management of neutropenia upon exposure to immune-checkpoint inhibitors: meta-analysis of a rare immune-related adverse side effect

Abstract Background Cancer immunotherapy via immune-checkpoint inhibition (ICI) by antibodies against cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and cell death protein 1 (PD-1) have significantly improved the outcome of metastasized melanoma and of a rapidly increasing number of other canc...

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Bibliographic Details
Main Authors: J. Boegeholz, C. S. Brueggen, C. Pauli, F. Dimitriou, E. Haralambieva, R. Dummer, M. G. Manz, C. C. Widmer
Format: Article
Language:English
Published: BMC 2020-04-01
Series:BMC Cancer
Subjects:
Immune-checkpoints-inhibitor
Neutropenia
Metamizole
Hematological side effects
Immune-related adverse events
Online Access:http://link.springer.com/article/10.1186/s12885-020-06763-y

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