Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils

<p>Abstract</p> <p>Background</p> <p>Granulocytes are important in the pathogenesis of several inflammatory diseases. Apoptosis is pivotal in the resolution of inflammation. Apoptosis in malignant cells is induced by histone deacetylase (HDAC) inhibitors, whereas HDAC i...

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Bibliographic Details
Main Authors: Adcock Ian M, Ito Misako, Jalonen Ulla, Ito Kazuhiro, Ilmarinen-Salo Pinja, Janka-Junttila Mirkka, Kankaanranta Hannu, Moilanen Eeva, Zhang Xianzhi
Format: Article
Language:English
Published: BMC 2010-02-01
Series:Journal of Inflammation
Online Access:http://www.journal-inflammation.com/content/7/1/9