Granular cell tumor: case report in an uncommon location

• Main Authors: Luciano Roberto Dipe, Andresa Borges Soares, Vera Cavalcanti de Araújo, Cristiane Furuse
• Format: Article
• Language: English
• Published: Faculdade São Leopoldo Mandic 2008-01-01
• Series: RGO: Revista Gaúcha de Odontologia
• Subjects: tumor de células granulares; diagnóstico; imunoistoquímica; granular cell tumor; diagnosis; immunohistochemistry
• Online Access: http://www.revistargo.com.br/include/getdoc.php?id=1807&article=886&mode=pdf

Granular cell tumor is a relatively rare, benign neoplasia that can occur in any part of the body, and in the oral cavity, the tongue is the location most commonly affected. They are generally nodular, single, well delimited, asymptomatic, slow growing, and most frequent in women during the fourth and sixth decades of life. Histologically it is characterized by a proliferation of polygonal cells with a granular appearance, which group themselves in nests, cords or sheets and present a strong immunohistochemical marker for S-100 protein,and a pseudoepitheliomatous hyperplasia can also be present. The treatment of choice is its complete surgical removal and in general,the prognosis is good, with rare recurrences, however cases of local aggressiveness and malign transformation have been related in theliterature. The aim of this article was to relate a clinical case of granular cell tumor located in an uncommon site, showing its clinical,histopathologic and immunohistochemical aspects and forms of treatment.