MDM4 overexpressed in acute myeloid leukemia patients with complex karyotype and wild-type TP53.

MDM4 overexpressed in acute myeloid leukemia patients with complex karyotype and wild-type TP53.

Acute myeloid leukemia patients with complex karyotype (CK-AML) account for approximately 10-15% of adult AML cases, and are often associated with a poor prognosis. Except for about 70% of CK-AML patients with biallelic inactivation of TP53, the leukemogenic mechanism in the nearly 30% of CK-AML pat...

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Bibliographic Details
Main Authors: Li Li, Yanhong Tan, Xiuhua Chen, Zhifang Xu, Siyao Yang, Fanggang Ren, Haixiu Guo, Xiaojuan Wang, Yi Chen, Guoxia Li, Hongwei Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4236138?pdf=render

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http://europepmc.org/articles/PMC4236138?pdf=render

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