Multiplex flow magnetic tweezers reveal rare enzymatic events with single molecule precision

Single molecule force measurements have shed light on dynamic biological events, but rare events escape notice owing to low throughput of the methods. Here, the authors combine an array of magnetic tweezers with lateral flow to increase throughput 100-fold, and detect rare DNA breaks induced by gyra...

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Bibliographic Details
Main Authors: Rohit Agarwal, Karl E. Duderstadt
Format: Article
Language:English
Published: Nature Publishing Group 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18456-y