Piecemeal Buildup of the Genetic Code, Ribosomes, and Genomes from Primordial tRNA Building Blocks

Piecemeal Buildup of the Genetic Code, Ribosomes, and Genomes from Primordial tRNA Building Blocks

The origin of biomolecular machinery likely centered around an ancient and central molecule capable of interacting with emergent macromolecular complexity. tRNA is the oldest and most central nucleic acid molecule of the cell. Its co-evolutionary interactions with aminoacyl-tRNA synthetase protein e...

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Bibliographic Details
Main Authors: Derek Caetano-Anollés, Gustavo Caetano-Anollés
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Life
Subjects:
genome evolution
origin of proteins
ribosome evolution
origin of the genetic code
Online Access:http://www.mdpi.com/2075-1729/6/4/43

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