Beyond T Cells: Understanding the Role of PD-1/PD-L1 in Tumor-Associated Macrophages

Programmed cell death protein 1 (PD-1) and its ligand PD-L1 have attracted wide attention from researchers in the field of immunotherapy. PD-1/PD-L1 have been shown to exist in many types of cells in addition to T lymphocytes, and studies have accordingly extended from their suppressive effect on T...

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Main Authors:	Di Lu, Zhen Ni, Xiguang Liu, Siyang Feng, Xiaoying Dong, Xiaoshun Shi, Jianxue Zhai, Shijie Mai, Jianjun Jiang, Zhizhi Wang, Hua Wu, Kaican Cai
Format:	Article
Language:	English
Published:	Hindawi Limited 2019-01-01
Series:	Journal of Immunology Research
Online Access:	http://dx.doi.org/10.1155/2019/1919082

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spelling	doaj-d561107739124050beb87d6c2101b9952020-11-25T01:34:56ZengHindawi LimitedJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/19190821919082Beyond T Cells: Understanding the Role of PD-1/PD-L1 in Tumor-Associated MacrophagesDi Lu0Zhen Ni1Xiguang Liu2Siyang Feng3Xiaoying Dong4Xiaoshun Shi5Jianxue Zhai6Shijie Mai7Jianjun Jiang8Zhizhi Wang9Hua Wu10Kaican Cai11Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, ChinaDepartment of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, ChinaDepartment of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, ChinaDepartment of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, ChinaDepartment of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, ChinaDepartment of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, ChinaDepartment of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, ChinaDepartment of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, ChinaDepartment of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, ChinaDepartment of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, ChinaDepartment of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, ChinaDepartment of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, ChinaProgrammed cell death protein 1 (PD-1) and its ligand PD-L1 have attracted wide attention from researchers in the field of immunotherapy. PD-1/PD-L1 have been shown to exist in many types of cells in addition to T lymphocytes, and studies have accordingly extended from their suppressive effect on T cell activation and function to examining their role in other cells. In this review, we summarize recent research on PD-1/PD-L1 in macrophages, with the aim of furthering our understanding of PD-1/PD-L1 and their detailed roles in macrophages. This information may provide additional insights for researchers, enrich the basic theory of anti-PD-1/PD-L1 immunotherapy, and thus ultimately benefit more patients.http://dx.doi.org/10.1155/2019/1919082
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Di Lu Zhen Ni Xiguang Liu Siyang Feng Xiaoying Dong Xiaoshun Shi Jianxue Zhai Shijie Mai Jianjun Jiang Zhizhi Wang Hua Wu Kaican Cai
spellingShingle	Di Lu Zhen Ni Xiguang Liu Siyang Feng Xiaoying Dong Xiaoshun Shi Jianxue Zhai Shijie Mai Jianjun Jiang Zhizhi Wang Hua Wu Kaican Cai Beyond T Cells: Understanding the Role of PD-1/PD-L1 in Tumor-Associated Macrophages Journal of Immunology Research
author_facet	Di Lu Zhen Ni Xiguang Liu Siyang Feng Xiaoying Dong Xiaoshun Shi Jianxue Zhai Shijie Mai Jianjun Jiang Zhizhi Wang Hua Wu Kaican Cai
author_sort	Di Lu
title	Beyond T Cells: Understanding the Role of PD-1/PD-L1 in Tumor-Associated Macrophages
title_short	Beyond T Cells: Understanding the Role of PD-1/PD-L1 in Tumor-Associated Macrophages
title_full	Beyond T Cells: Understanding the Role of PD-1/PD-L1 in Tumor-Associated Macrophages
title_fullStr	Beyond T Cells: Understanding the Role of PD-1/PD-L1 in Tumor-Associated Macrophages
title_full_unstemmed	Beyond T Cells: Understanding the Role of PD-1/PD-L1 in Tumor-Associated Macrophages
title_sort	beyond t cells: understanding the role of pd-1/pd-l1 in tumor-associated macrophages
publisher	Hindawi Limited
series	Journal of Immunology Research
issn	2314-8861 2314-7156
publishDate	2019-01-01
description	Programmed cell death protein 1 (PD-1) and its ligand PD-L1 have attracted wide attention from researchers in the field of immunotherapy. PD-1/PD-L1 have been shown to exist in many types of cells in addition to T lymphocytes, and studies have accordingly extended from their suppressive effect on T cell activation and function to examining their role in other cells. In this review, we summarize recent research on PD-1/PD-L1 in macrophages, with the aim of furthering our understanding of PD-1/PD-L1 and their detailed roles in macrophages. This information may provide additional insights for researchers, enrich the basic theory of anti-PD-1/PD-L1 immunotherapy, and thus ultimately benefit more patients.
url	http://dx.doi.org/10.1155/2019/1919082
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Beyond T Cells: Understanding the Role of PD-1/PD-L1 in Tumor-Associated Macrophages

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