Combinatorial Effect of DCA and Let-7a on Triple-Negative MDA-MB-231 Cells: A Metabolic Approach of Treatment

Combinatorial Effect of DCA and Let-7a on Triple-Negative MDA-MB-231 Cells: A Metabolic Approach of Treatment

Dichloroacetate (DCA) is a metabolic modulator that inhibits pyruvate dehydrogenase activity and promotes the influx of pyruvate into the tricarboxylic acid cycle for complete oxidation of glucose. DCA stimulates oxidative phosphorylation (OXPHOS) more than glycolysis by altering the morphology of t...

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Bibliographic Details
Main Authors:	Praveen Sharma MSc, Sandeep Singh PhD
Format:	Article
Language:	English
Published:	SAGE Publishing 2020-04-01
Series:	Integrative Cancer Therapies
Online Access:	https://doi.org/10.1177/1534735420911437

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