Distinct roles of nonmuscle myosin II isoforms for establishing tension and elasticity during cell morphodynamics

Distinct roles of nonmuscle myosin II isoforms for establishing tension and elasticity during cell morphodynamics

Nonmuscle myosin II (NM II) is an integral part of essential cellular processes, including adhesion and migration. Mammalian cells express up to three isoforms termed NM IIA, B, and C. We used U2OS cells to create CRISPR/Cas9-based knockouts of all three isoforms and analyzed the phenotypes on homog...

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Bibliographic Details
Main Authors: Kai Weißenbruch, Justin Grewe, Marc Hippler, Magdalena Fladung, Moritz Tremmel, Kathrin Stricker, Ulrich Sebastian Schwarz, Martin Bastmeyer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
actomyosin
NM II isoforms
contractility
cell shape
intracellular forces
mathematical modeling
Online Access:https://elifesciences.org/articles/71888

Internet

https://elifesciences.org/articles/71888

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