Generation of patient-specific induced pluripotent stem cells (ZZUSAHi001-A) derived from a familial atrial fibrillation patient carrying KCNA5 c.775G>A mutation

Generation of patient-specific induced pluripotent stem cells (ZZUSAHi001-A) derived from a familial atrial fibrillation patient carrying KCNA5 c.775G>A mutation

Peripheral blood mononuclear cells (PBMCs) were isolated from a 57-year-old female who was clinically diagnosed as familial atrial fibrillation and were reprogrammed using non-integrative Sendai viral vectors containing reprogramming factors OCT4, SOX2, KLF4 and cMYC. The generated human induced plu...

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Main Authors: Shaohui Niu, Haiyan Xiong, Yuan Li, Lihua Zhang
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506120302166
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spelling doaj-d552a852af0644d99607a073796366b72020-11-25T03:41:17ZengElsevierStem Cell Research1873-50612020-08-0147101915Generation of patient-specific induced pluripotent stem cells (ZZUSAHi001-A) derived from a familial atrial fibrillation patient carrying KCNA5 c.775G>A mutationShaohui Niu0Haiyan Xiong1Yuan Li2Lihua Zhang3Department of Cardiology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaCorresponding author at: The Second Affiliated Hospital of Zhengzhou University, Zhengzhou University, Jingba Road No. 2, Jinshui District, Zhengzhou 450052, China.; Department of Cardiology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaPeripheral blood mononuclear cells (PBMCs) were isolated from a 57-year-old female who was clinically diagnosed as familial atrial fibrillation and were reprogrammed using non-integrative Sendai viral vectors containing reprogramming factors OCT4, SOX2, KLF4 and cMYC. The generated human induced pluripotent stem cell (hiPSC) line, ZZUSAHi001-A, exhibited a normal karyotype, showed robust expression of pluripotency markers and differentiated towards three germ layers in vivo.http://www.sciencedirect.com/science/article/pii/S1873506120302166
collection DOAJ
language English
format Article
sources DOAJ
author Shaohui Niu
Haiyan Xiong
Yuan Li
Lihua Zhang
spellingShingle Shaohui Niu
Haiyan Xiong
Yuan Li
Lihua Zhang
Generation of patient-specific induced pluripotent stem cells (ZZUSAHi001-A) derived from a familial atrial fibrillation patient carrying KCNA5 c.775G>A mutation
Stem Cell Research
author_facet Shaohui Niu
Haiyan Xiong
Yuan Li
Lihua Zhang
author_sort Shaohui Niu
title Generation of patient-specific induced pluripotent stem cells (ZZUSAHi001-A) derived from a familial atrial fibrillation patient carrying KCNA5 c.775G>A mutation
title_short Generation of patient-specific induced pluripotent stem cells (ZZUSAHi001-A) derived from a familial atrial fibrillation patient carrying KCNA5 c.775G>A mutation
title_full Generation of patient-specific induced pluripotent stem cells (ZZUSAHi001-A) derived from a familial atrial fibrillation patient carrying KCNA5 c.775G>A mutation
title_fullStr Generation of patient-specific induced pluripotent stem cells (ZZUSAHi001-A) derived from a familial atrial fibrillation patient carrying KCNA5 c.775G>A mutation
title_full_unstemmed Generation of patient-specific induced pluripotent stem cells (ZZUSAHi001-A) derived from a familial atrial fibrillation patient carrying KCNA5 c.775G>A mutation
title_sort generation of patient-specific induced pluripotent stem cells (zzusahi001-a) derived from a familial atrial fibrillation patient carrying kcna5 c.775g>a mutation
publisher Elsevier
series Stem Cell Research
issn 1873-5061
publishDate 2020-08-01
description Peripheral blood mononuclear cells (PBMCs) were isolated from a 57-year-old female who was clinically diagnosed as familial atrial fibrillation and were reprogrammed using non-integrative Sendai viral vectors containing reprogramming factors OCT4, SOX2, KLF4 and cMYC. The generated human induced pluripotent stem cell (hiPSC) line, ZZUSAHi001-A, exhibited a normal karyotype, showed robust expression of pluripotency markers and differentiated towards three germ layers in vivo.
url http://www.sciencedirect.com/science/article/pii/S1873506120302166
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AT haiyanxiong generationofpatientspecificinducedpluripotentstemcellszzusahi001aderivedfromafamilialatrialfibrillationpatientcarryingkcna5c775gamutation
AT yuanli generationofpatientspecificinducedpluripotentstemcellszzusahi001aderivedfromafamilialatrialfibrillationpatientcarryingkcna5c775gamutation
AT lihuazhang generationofpatientspecificinducedpluripotentstemcellszzusahi001aderivedfromafamilialatrialfibrillationpatientcarryingkcna5c775gamutation
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