Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular Testing

Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular Testing

When extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue (MALT), a low grade B-cell lymphoma, arises in the lung it is referred to as bronchus-associated lymphoid tissue (BALT) lymphoma. We describe a patient with a history of Sjögren’s syndrome and rheumatoid arthritis wit...

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Main Authors: Pen Li, Lawrence Cheung, Brian Chiu
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Canadian Respiratory Journal
Online Access:http://dx.doi.org/10.1155/2016/7056035
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spelling doaj-d54dfa610f9a471f816f44a3228f44542021-07-02T04:26:02ZengHindawi LimitedCanadian Respiratory Journal1198-22411916-72452016-01-01201610.1155/2016/70560357056035Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular TestingPen Li0Lawrence Cheung1Brian Chiu2Department of Medicine, University of Alberta, Edmonton, AB, T6G 2G3, CanadaDepartment of Medicine, University of Alberta, Edmonton, AB, T6G 2G3, CanadaDepartment of Laboratory-Medicine and Pathology, University of Alberta, Edmonton, AB, T6G 2B7, CanadaWhen extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue (MALT), a low grade B-cell lymphoma, arises in the lung it is referred to as bronchus-associated lymphoid tissue (BALT) lymphoma. We describe a patient with a history of Sjögren’s syndrome and rheumatoid arthritis with dyspnea and imaging consistent with lymphoid interstitial pneumonia (LIP). However, while histology and immunohistochemistry lacked definitive features of a lymphoma, immunoglobulin heavy chain (IgH) polymerase chain reaction testing demonstrated B-cell monoclonality, consistent with an early BALT lymphoma.http://dx.doi.org/10.1155/2016/7056035
collection DOAJ
language English
format Article
sources DOAJ
author Pen Li
Lawrence Cheung
Brian Chiu
spellingShingle Pen Li
Lawrence Cheung
Brian Chiu
Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular Testing
Canadian Respiratory Journal
author_facet Pen Li
Lawrence Cheung
Brian Chiu
author_sort Pen Li
title Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular Testing
title_short Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular Testing
title_full Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular Testing
title_fullStr Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular Testing
title_full_unstemmed Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular Testing
title_sort early bronchus-associated lymphoid tissue lymphoma diagnosed with immunoglobulin heavy chain molecular testing
publisher Hindawi Limited
series Canadian Respiratory Journal
issn 1198-2241
1916-7245
publishDate 2016-01-01
description When extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue (MALT), a low grade B-cell lymphoma, arises in the lung it is referred to as bronchus-associated lymphoid tissue (BALT) lymphoma. We describe a patient with a history of Sjögren’s syndrome and rheumatoid arthritis with dyspnea and imaging consistent with lymphoid interstitial pneumonia (LIP). However, while histology and immunohistochemistry lacked definitive features of a lymphoma, immunoglobulin heavy chain (IgH) polymerase chain reaction testing demonstrated B-cell monoclonality, consistent with an early BALT lymphoma.
url http://dx.doi.org/10.1155/2016/7056035
work_keys_str_mv AT penli earlybronchusassociatedlymphoidtissuelymphomadiagnosedwithimmunoglobulinheavychainmoleculartesting
AT lawrencecheung earlybronchusassociatedlymphoidtissuelymphomadiagnosedwithimmunoglobulinheavychainmoleculartesting
AT brianchiu earlybronchusassociatedlymphoidtissuelymphomadiagnosedwithimmunoglobulinheavychainmoleculartesting
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