The Role of Low Complexity Regions in Protein Interaction Modes: An Illustration in Huntingtin
Low complexity regions (LCRs) are very frequent in protein sequences, generally having a lower propensity to form structured domains and tending to be much less evolutionarily conserved than globular domains. Their higher abundance in eukaryotes and in species with more cellular types agrees with a...
Main Authors: | Kristina Kastano, Pablo Mier, Miguel A. Andrade-Navarro |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-02-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/22/4/1727 |
Similar Items
-
The Conservation of Low Complexity Regions in Bacterial Proteins Depends on the Pathogenicity of the Strain and Subcellular Location of the Protein
by: Pablo Mier, et al.
Published: (2021-03-01) -
Intrinsic Disorder in Proteins with Pathogenic Repeat Expansions
by: April L. Darling, et al.
Published: (2017-11-01) -
Evolutionary Study of Disorder in Protein Sequences
by: Kristina Kastano, et al.
Published: (2020-10-01) -
The features of polyglutamine regions depend on their evolutionary stability
by: Pablo Mier, et al.
Published: (2020-05-01) -
A New Census of Protein Tandem Repeats and Their Relationship with Intrinsic Disorder
by: Matteo Delucchi, et al.
Published: (2020-04-01)