Effects of insulin-loaded chitosan-alginate nanoparticle on RAGE expression and oxidative stress status in the kidney tissue of rats with type 1 diabetes

Effects of insulin-loaded chitosan-alginate nanoparticle on RAGE expression and oxidative stress status in the kidney tissue of rats with type 1 diabetes

Objective(s): Chronic hyperglycemia leads to activation of the advanced glycation end products (AGE)-receptor (RAGE) for AGE axis and oxidative stress, which promote diabetic renal damage. This study examines the effect of insulin-loaded trimethyl chitosan nanoparticles on the kidney tissue of diabe...

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Bibliographic Details
Main Authors: Shirin Heidarisasan, Nasrin Ziamajidi, Jamshid Karimi, Roghayeh Abbasalipourkabir
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2018-10-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
AGE
Antioxidant
Diabetes mellitus
Insulin
Nanoparticles
Oxidant
Online Access:http://ijbms.mums.ac.ir/article_11328_5c92dea126b54cbbea11c64f99985ee8.pdf

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