Increased Akt-Driven Glycolysis Is the Basis for the Higher Potency of CD137L-DCs

Increased Akt-Driven Glycolysis Is the Basis for the Higher Potency of CD137L-DCs

CD137 ligand-induced dendritic cells (CD137L-DCs) are a new type of dendritic cells (DCs) that induce strong cytotoxic T cell responses. Investigating the metabolic activity as a potential contributing factor for their potency, we find a significantly higher rate of glycolysis in CD137L-DCs than in...

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Bibliographic Details
Main Authors: Qun Zeng, Karthik Mallilankaraman, Herbert Schwarz
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
CD137L-DC
metabolism
glycolysis
Akt
mTOR
lipid synthesis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00868/full

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