Acute Metabolic Effects of Thiopental Anesthesia on Fed and Fasted Rats Chronically Treated With Bromocriptine

We investigated the acute effects of thiopental anesthesia (4 mg/100 g, i.v.) on plasma glucose, insulin, triacylglycerol, and prolactin levels in rats treated with bromocriptine (BR) (0.4 mg/100 g body wt, i.p., for two weeks). Thiopental anesthesia induced a rapid increase in plasma insulin that w...

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Main Authors:	Antônio Ribeiro de Oliveira, Jr., Leida Maria Botion, Rachel Menezes Guerra, Rodrigo Bastos Fóscolo, Lucas José Campos Machado, Umeko Marubayashi, Adelina Martha dos Reis, Câ;ndido Celso Coimbra
Format:	Article
Language:	English
Published:	Elsevier 2003-01-01
Series:	Journal of Pharmacological Sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861319326775

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spelling	doaj-d52a51397f2d47e294022ad4d996d6512020-11-24T23:52:10ZengElsevierJournal of Pharmacological Sciences1347-86132003-01-01922149152Acute Metabolic Effects of Thiopental Anesthesia on Fed and Fasted Rats Chronically Treated With BromocriptineAntônio Ribeiro de Oliveira, Jr.0Leida Maria Botion1Rachel Menezes Guerra2Rodrigo Bastos Fóscolo3Lucas José Campos Machado4Umeko Marubayashi5Adelina Martha dos Reis6Câ;ndido Celso Coimbra7Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, 6627 Av. Antônio Carlos, 31270-901 Belo Horizonte, Minas Gerais, Brazil; Department of Internal Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, BrazilDepartment of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, 6627 Av. Antônio Carlos, 31270-901 Belo Horizonte, Minas Gerais, BrazilDepartment of Internal Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, BrazilDepartment of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, 6627 Av. Antônio Carlos, 31270-901 Belo Horizonte, Minas Gerais, BrazilDepartment of Internal Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, BrazilDepartment of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, 6627 Av. Antônio Carlos, 31270-901 Belo Horizonte, Minas Gerais, BrazilDepartment of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, 6627 Av. Antônio Carlos, 31270-901 Belo Horizonte, Minas Gerais, BrazilDepartment of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, 6627 Av. Antônio Carlos, 31270-901 Belo Horizonte, Minas Gerais, BrazilWe investigated the acute effects of thiopental anesthesia (4 mg/100 g, i.v.) on plasma glucose, insulin, triacylglycerol, and prolactin levels in rats treated with bromocriptine (BR) (0.4 mg/100 g body wt, i.p., for two weeks). Thiopental anesthesia induced a rapid increase in plasma insulin that was more pronounced in the animals treated with BR (116%, P<0.05). Thiopental anesthesia also produced a 55% decreased in plasma prolactin levels (P<0.01) in control fed rats, and a 22% reduction in plasma triacylglycerol (P<0.05) in both controls and BR-treated rats. We conclude that BR may constitute and additional sympatholytic factor in animals submitted to thiopental anesthesia.http://www.sciencedirect.com/science/article/pii/S1347861319326775
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Antônio Ribeiro de Oliveira, Jr. Leida Maria Botion Rachel Menezes Guerra Rodrigo Bastos Fóscolo Lucas José Campos Machado Umeko Marubayashi Adelina Martha dos Reis Câ;ndido Celso Coimbra
spellingShingle	Antônio Ribeiro de Oliveira, Jr. Leida Maria Botion Rachel Menezes Guerra Rodrigo Bastos Fóscolo Lucas José Campos Machado Umeko Marubayashi Adelina Martha dos Reis Câ;ndido Celso Coimbra Acute Metabolic Effects of Thiopental Anesthesia on Fed and Fasted Rats Chronically Treated With Bromocriptine Journal of Pharmacological Sciences
author_facet	Antônio Ribeiro de Oliveira, Jr. Leida Maria Botion Rachel Menezes Guerra Rodrigo Bastos Fóscolo Lucas José Campos Machado Umeko Marubayashi Adelina Martha dos Reis Câ;ndido Celso Coimbra
author_sort	Antônio Ribeiro de Oliveira, Jr.
title	Acute Metabolic Effects of Thiopental Anesthesia on Fed and Fasted Rats Chronically Treated With Bromocriptine
title_short	Acute Metabolic Effects of Thiopental Anesthesia on Fed and Fasted Rats Chronically Treated With Bromocriptine
title_full	Acute Metabolic Effects of Thiopental Anesthesia on Fed and Fasted Rats Chronically Treated With Bromocriptine
title_fullStr	Acute Metabolic Effects of Thiopental Anesthesia on Fed and Fasted Rats Chronically Treated With Bromocriptine
title_full_unstemmed	Acute Metabolic Effects of Thiopental Anesthesia on Fed and Fasted Rats Chronically Treated With Bromocriptine
title_sort	acute metabolic effects of thiopental anesthesia on fed and fasted rats chronically treated with bromocriptine
publisher	Elsevier
series	Journal of Pharmacological Sciences
issn	1347-8613
publishDate	2003-01-01
description	We investigated the acute effects of thiopental anesthesia (4 mg/100 g, i.v.) on plasma glucose, insulin, triacylglycerol, and prolactin levels in rats treated with bromocriptine (BR) (0.4 mg/100 g body wt, i.p., for two weeks). Thiopental anesthesia induced a rapid increase in plasma insulin that was more pronounced in the animals treated with BR (116%, P<0.05). Thiopental anesthesia also produced a 55% decreased in plasma prolactin levels (P<0.01) in control fed rats, and a 22% reduction in plasma triacylglycerol (P<0.05) in both controls and BR-treated rats. We conclude that BR may constitute and additional sympatholytic factor in animals submitted to thiopental anesthesia.
url	http://www.sciencedirect.com/science/article/pii/S1347861319326775
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Acute Metabolic Effects of Thiopental Anesthesia on Fed and Fasted Rats Chronically Treated With Bromocriptine

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