Acute Metabolic Effects of Thiopental Anesthesia on Fed and Fasted Rats Chronically Treated With Bromocriptine

Acute Metabolic Effects of Thiopental Anesthesia on Fed and Fasted Rats Chronically Treated With Bromocriptine

We investigated the acute effects of thiopental anesthesia (4 mg/100 g, i.v.) on plasma glucose, insulin, triacylglycerol, and prolactin levels in rats treated with bromocriptine (BR) (0.4 mg/100 g body wt, i.p., for two weeks). Thiopental anesthesia induced a rapid increase in plasma insulin that w...

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Bibliographic Details
Main Authors: Antônio Ribeiro de Oliveira, Jr., Leida Maria Botion, Rachel Menezes Guerra, Rodrigo Bastos Fóscolo, Lucas José Campos Machado, Umeko Marubayashi, Adelina Martha dos Reis, Câ;ndido Celso Coimbra
Format: Article
Language:English
Published: Elsevier 2003-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319326775
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Summary:We investigated the acute effects of thiopental anesthesia (4 mg/100 g, i.v.) on plasma glucose, insulin, triacylglycerol, and prolactin levels in rats treated with bromocriptine (BR) (0.4 mg/100 g body wt, i.p., for two weeks). Thiopental anesthesia induced a rapid increase in plasma insulin that was more pronounced in the animals treated with BR (116%, P<0.05). Thiopental anesthesia also produced a 55% decreased in plasma prolactin levels (P<0.01) in control fed rats, and a 22% reduction in plasma triacylglycerol (P<0.05) in both controls and BR-treated rats. We conclude that BR may constitute and additional sympatholytic factor in animals submitted to thiopental anesthesia.
ISSN:1347-8613

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