Chimeric antigen receptor T cell therapies for multiple myeloma

• Main Authors: Chao Wu, Lina Zhang, Qierra R. Brockman, Fenghuang Zhan, Lijuan Chen
• Format: Article
• Language: English
• Published: BMC 2019-11-01
• Series: Journal of Hematology & Oncology
• Subjects: Chimeric antigen receptors; Multiple myeloma; Immunotherapy; Tumor immunology
• Online Access: http://link.springer.com/article/10.1186/s13045-019-0823-5

Abstract Multiple myeloma (MM) is the second most common hematologic malignancy and remains incurable despite the advent of numerous new drugs such as proteasome inhibitors (PIs), immunomodulatory agents (IMiDs), and monoclonal antibodies. There is an unmet need to develop novel therapies for refractory/relapsed MM. In the past few years, chimeric antigen receptor (CAR)-modified T cell therapy for MM has shown promising efficacy in preclinical and clinical studies. Furthermore, the toxicities of CAR-T cell therapy are manageable. This article summarizes recent developments of CAR-T therapy in MM, focusing on promising targets, new technologies, and new research areas. Additionally, a comprehensive overview of antigen selection is presented along with preliminary results and future directions of CAR-T therapy development.