Small molecule activators of the Trk receptors for neuroprotection
<p>Abstract</p> <p>The neurotophin signaling network is critical to the development and survival of many neuronal populations. Especially sensitive to imbalances in the neurotrophin system, cholinergic neurons in the basal forebrain are progressively lost in Alzheimer's diseas...
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BMC
2008-12-01
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| Series: | BMC Neuroscience |
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doaj-d52581f6314a4227955f477ff07bf95c2020-11-25T00:37:57ZengBMCBMC Neuroscience1471-22022008-12-019Suppl 2S110.1186/1471-2202-9-S2-S1Small molecule activators of the Trk receptors for neuroprotectionWebster Nicholas JGPirrung Michael C<p>Abstract</p> <p>The neurotophin signaling network is critical to the development and survival of many neuronal populations. Especially sensitive to imbalances in the neurotrophin system, cholinergic neurons in the basal forebrain are progressively lost in Alzheimer's disease. Therapeutic use of neurotrophins to prevent this loss is hampered, however, by a number of pharmacological challenges. These include a lack of transport across the blood-brain barrier, rapid degradation in the circulation, and difficulty in production. In this review we discuss the evidence supporting the neurotrophin system's role in preventing neurodegeneration and survey some of the pharmacological strategies being pursued to develop effective therapeutics targeting neurotrophin function.</p> |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Webster Nicholas JG Pirrung Michael C |
| spellingShingle |
Webster Nicholas JG Pirrung Michael C Small molecule activators of the Trk receptors for neuroprotection BMC Neuroscience |
| author_facet |
Webster Nicholas JG Pirrung Michael C |
| author_sort |
Webster Nicholas JG |
| title |
Small molecule activators of the Trk receptors for neuroprotection |
| title_short |
Small molecule activators of the Trk receptors for neuroprotection |
| title_full |
Small molecule activators of the Trk receptors for neuroprotection |
| title_fullStr |
Small molecule activators of the Trk receptors for neuroprotection |
| title_full_unstemmed |
Small molecule activators of the Trk receptors for neuroprotection |
| title_sort |
small molecule activators of the trk receptors for neuroprotection |
| publisher |
BMC |
| series |
BMC Neuroscience |
| issn |
1471-2202 |
| publishDate |
2008-12-01 |
| description |
<p>Abstract</p> <p>The neurotophin signaling network is critical to the development and survival of many neuronal populations. Especially sensitive to imbalances in the neurotrophin system, cholinergic neurons in the basal forebrain are progressively lost in Alzheimer's disease. Therapeutic use of neurotrophins to prevent this loss is hampered, however, by a number of pharmacological challenges. These include a lack of transport across the blood-brain barrier, rapid degradation in the circulation, and difficulty in production. In this review we discuss the evidence supporting the neurotrophin system's role in preventing neurodegeneration and survey some of the pharmacological strategies being pursued to develop effective therapeutics targeting neurotrophin function.</p> |
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AT websternicholasjg smallmoleculeactivatorsofthetrkreceptorsforneuroprotection AT pirrungmichaelc smallmoleculeactivatorsofthetrkreceptorsforneuroprotection |
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