pH-Induced Folding of the Caspase-Cleaved Par-4 Tumor Suppressor: Evidence of Structure Outside of the Coiled Coil Domain

pH-Induced Folding of the Caspase-Cleaved Par-4 Tumor Suppressor: Evidence of Structure Outside of the Coiled Coil Domain

Prostate apoptosis response-4 (Par-4) is a 38 kDa largely intrinsically disordered tumor suppressor protein that functions in cancer cell apoptosis. Par-4 down-regulation is often observed in cancer while up-regulation is characteristic of neurodegenerative conditions such as Alzheimer’s d...

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Bibliographic Details
Main Authors: Andrea M. Clark, Komala Ponniah, Meghan S. Warden, Emily M. Raitt, Andrea C. Yawn, Steven M. Pascal
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Biomolecules
Subjects:
prostate apoptosis response-4 (Par-4)
intrinsically disordered protein (IDP)
cancer
circular dichroism
coiled coil (CC), leucine zipper (LZ), apoptosis
Online Access:https://www.mdpi.com/2218-273X/8/4/162

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https://www.mdpi.com/2218-273X/8/4/162

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