Distinct Single Cell Gene Expression in Peripheral Blood Monocytes Correlates With Tumor Necrosis Factor Inhibitor Treatment Response Groups Defined by Type I Interferon in Rheumatoid Arthritis

Distinct Single Cell Gene Expression in Peripheral Blood Monocytes Correlates With Tumor Necrosis Factor Inhibitor Treatment Response Groups Defined by Type I Interferon in Rheumatoid Arthritis

Previously, we demonstrated in test and validation cohorts that type I IFN (T1IFN) activity can predict non-response to tumor necrosis factor inhibitors (TNFi) in rheumatoid arthritis (RA). In this study, we examine the biology of non-classical and classical monocytes from RA patients defined by the...

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Bibliographic Details
Main Authors: Theresa L. Wampler Muskardin, Wei Fan, Zhongbo Jin, Mark A. Jensen, Jessica M. Dorschner, Yogita Ghodke-Puranik, Betty Dicke, Danielle Vsetecka, Kerry Wright, Thomas Mason, Scott Persellin, Clement J. Michet, John M. Davis, Eric Matteson, Timothy B. Niewold
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
type I interferon
tumor necrosis factor-alpha
monocyte
single cell
rheumatoid arthritis
janus kinase 1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01384/full

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