Kinins and Their Receptors in Infectious Diseases

Kinins and Their Receptors in Infectious Diseases

Kinins and their receptors have been implicated in a series of pathological alterations, representing attractive pharmacological targets for several diseases. The present review article aims to discuss the role of the kinin system in infectious diseases. Literature data provides compelling evidence...

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Main Authors: Ana Paula A. Dagnino, Maria M. Campos, Rodrigo B. M. Silva
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Pharmaceuticals
Subjects:
bradykinin
B<sub>1</sub> receptors
B<sub>2</sub> receptors
infection
therapeutics
Online Access:https://www.mdpi.com/1424-8247/13/9/215
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spelling doaj-d51fd9a9fdad49ecae093bad2483cc192020-11-25T03:55:48ZengMDPI AGPharmaceuticals1424-82472020-08-011321521510.3390/ph13090215Kinins and Their Receptors in Infectious DiseasesAna Paula A. Dagnino0Maria M. Campos1Rodrigo B. M. Silva2Centro de Pesquisa em Toxicologia e Farmacologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS 90619-900, BrazilCentro de Pesquisa em Toxicologia e Farmacologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS 90619-900, BrazilCentro de Pesquisa em Toxicologia e Farmacologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS 90619-900, BrazilKinins and their receptors have been implicated in a series of pathological alterations, representing attractive pharmacological targets for several diseases. The present review article aims to discuss the role of the kinin system in infectious diseases. Literature data provides compelling evidence about the participation of kinins in infections caused by diverse agents, including viral, bacterial, fungal, protozoan, and helminth-related ills. It is tempting to propose that modulation of kinin actions and production might be an adjuvant strategy for management of infection-related complications.https://www.mdpi.com/1424-8247/13/9/215bradykininB<sub>1</sub> receptorsB<sub>2</sub> receptorsinfectiontherapeutics
collection DOAJ
language English
format Article
sources DOAJ
author Ana Paula A. Dagnino
Maria M. Campos
Rodrigo B. M. Silva
spellingShingle Ana Paula A. Dagnino
Maria M. Campos
Rodrigo B. M. Silva
Kinins and Their Receptors in Infectious Diseases
Pharmaceuticals
bradykinin
B<sub>1</sub> receptors
B<sub>2</sub> receptors
infection
therapeutics
author_facet Ana Paula A. Dagnino
Maria M. Campos
Rodrigo B. M. Silva
author_sort Ana Paula A. Dagnino
title Kinins and Their Receptors in Infectious Diseases
title_short Kinins and Their Receptors in Infectious Diseases
title_full Kinins and Their Receptors in Infectious Diseases
title_fullStr Kinins and Their Receptors in Infectious Diseases
title_full_unstemmed Kinins and Their Receptors in Infectious Diseases
title_sort kinins and their receptors in infectious diseases
publisher MDPI AG
series Pharmaceuticals
issn 1424-8247
publishDate 2020-08-01
description Kinins and their receptors have been implicated in a series of pathological alterations, representing attractive pharmacological targets for several diseases. The present review article aims to discuss the role of the kinin system in infectious diseases. Literature data provides compelling evidence about the participation of kinins in infections caused by diverse agents, including viral, bacterial, fungal, protozoan, and helminth-related ills. It is tempting to propose that modulation of kinin actions and production might be an adjuvant strategy for management of infection-related complications.
topic bradykinin
B<sub>1</sub> receptors
B<sub>2</sub> receptors
infection
therapeutics
url https://www.mdpi.com/1424-8247/13/9/215
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