Omega-3 Polyunsaturated Fatty Acid Supplementation Reduced Atrial Fibrillation Recurrence after Pulmonary Vein Antrum Isolation

• Main Authors: Dimpi Patel, Mazen Shaheen, Preeti Venkatraman, Luciana Armaganijan, Javier E Sanchez, Rodney P Horton, Luigi Di Biase, Prasant Mohanty, Robert Canby, Shane M Bailey, J David Burkhardt, G Joesph Gallinghouse, Jason D Zagrodzky, Marketa Kozeluhova, Andrea Natale
• Format: Article
• Language: English
• Published: Elsevier 2009-11-01
• Series: Indian Pacing and Electrophysiology Journal
• Subjects: Polyunsaturated Fatty acids (PUFA); Atrial Fibrillation (AF); Pulmonary vein isolation (PVAI)
• Online Access: http://www.ipej.org/0906/patel.htm

Objective: To assess if patients treated with omega-3(n-3) polyunsaturated fatty acids (PUFAS) had lower procedural failure rates compared to an untreated population.Methods and Results: From January 2004 to 2007, 1500 PVAI patients underwent catheter ablation. Two hundred and eighty five (19%) patients were treated with PUFAs. These patients were matched in a nested case controlled analysis. After matching, there were 129 patients in the PUFA group and 129 in the control group. Thirty-five (27.1%) patients in the study group had early recurrence vs. 57 (44.1%) in the control group p-value<0.0001. Twenty-nine (23.2%) patients in the PUFA group vs. 41 (31.7%) in the non-PUFA group had procedural failure (p-value <0.003). There were no significant differences in complications in the PUFA and non-PUFA groups.Conclusion: Patients treated with PUFAs had lower incidences of early recurrence and procedural failure compared to an untreated population.