Efficacy of 5-fluorouracil in combination with methoxyphenyl maleamic acid in murine tumors.

Efficacy of 5-fluorouracil in combination with methoxyphenyl maleamic acid in murine tumors.

Combination chemotherapy studies were carried out in vivo against sarcoma 180 (ascites)(S180) and Ehrlich (ascites) carcinoma (EAC) tumours using cytotoxic drugs and methoxyphenyl maleamic acid (MPMA), an intermediate in the synthesis of pyrrolidine-nitrogen-mustards. Preliminary data have suggested...

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Bibliographic Details
Main Authors: Indap M, Ambaye R
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 1991-10-01
Series:Journal of Postgraduate Medicine
Subjects:
Animal
Antineoplastic Combined Chemotherapy Protocols
therapeutic use
Carcinoma
Ehrlich Tumor
drug therapy
Drug Therapy
Combination
Female
Fluorouracil
administration & dosage
Male
Maleates
Mice
Random Allocation
Sarcoma 180
Online Access:http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1991;volume=37;issue=4;spage=211;epage=5;aulast=Indap
Description
Summary:Combination chemotherapy studies were carried out in vivo against sarcoma 180 (ascites)(S180) and Ehrlich (ascites) carcinoma (EAC) tumours using cytotoxic drugs and methoxyphenyl maleamic acid (MPMA), an intermediate in the synthesis of pyrrolidine-nitrogen-mustards. Preliminary data have suggested that the combination of 5-fluorouracil (5-FU) and methoxyphenyl maleamic acid (MPMA) was more active than 5-FU used singly against EAC tumour. The possible therapeutic potential of this combination was further investigated in EAC tumour.
ISSN:0022-3859
0972-2823

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