Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency
The pathways involved in exit from pluripotency in human embryonic stem cells are poorly understood. Here, the authors performed a CRISPR-based screen to identify genes that promote exit from naïve pluripotency and find a role for folliculin (FLCN) by regulating the mTOR and Wnt pathways.
Bibliographic Details
| Main Authors: |
J. Mathieu,
D. Detraux,
D. Kuppers,
Y. Wang,
C. Cavanaugh,
S. Sidhu,
S. Levy,
A. M. Robitaille,
A. Ferreccio,
T. Bottorff,
A. McAlister,
L. Somasundaram,
F. Artoni,
S. Battle,
R. D. Hawkins,
R. T. Moon,
C. B. Ware,
P. J. Paddison,
H. Ruohola-Baker |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2019-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-08020-0
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