The Treg-specific demethylated region stabilizes Foxp3 expression independently of NF-κB signaling.

The Treg-specific demethylated region stabilizes Foxp3 expression independently of NF-κB signaling.

Regulatory T cells (Tregs) obtain immunosuppressive capacity by the upregulation of forkhead box protein 3 (Foxp3), and persistent expression of this transcription factor is required to maintain their immune regulatory function and ensure immune homeostasis. Stable Foxp3 expression is achieved throu...

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Bibliographic Details
Main Authors: Lisa Schreiber, Beate Pietzsch, Stefan Floess, Carla Farah, Lothar Jänsch, Ingo Schmitz, Jochen Huehn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3914969?pdf=render

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