Hypoxia Inducible Factor 1A Supports a Pro-Fibrotic Phenotype Loop in Idiopathic Pulmonary Fibrosis

Hypoxia Inducible Factor 1A Supports a Pro-Fibrotic Phenotype Loop in Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis. The IPF-conditioned matrix (IPF-CM) system enables the study of matrix–fibroblast interplay. While effective at slowing fibrosis, nintedanib has limitations and the mechanism is not fully elucidated. In the curren...

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Bibliographic Details
Main Authors: Gali Epstein Shochet, Becky Bardenstein-Wald, Mary McElroy, Andrew Kukuy, Mark Surber, Evgeny Edelstein, Barak Pertzov, Mordechai Reuven Kramer, David Shitrit
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
IPF
HIF1A
PAI-1
extracellular matrix
bleomycin
nintedanib
Online Access:https://www.mdpi.com/1422-0067/22/7/3331

Internet

https://www.mdpi.com/1422-0067/22/7/3331

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