Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels
The activity of serotonin (5-HT) neurons is critical for mood regulation. In a mouse model of chronic social isolation, a known risk factor for depressive illness, we show that 5-HT neurons in the dorsal raphe nucleus are less responsive to stimulation. Probing the responsible cellular mechanisms pi...
Main Authors: | Derya Sargin, David K Oliver, Evelyn K Lambe |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2016-11-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/21416 |
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