Creating a ‘Molecular Band-Aid’; Blocking an Exposed Protease Target Site in Desmoplakin

Creating a ‘Molecular Band-Aid’; Blocking an Exposed Protease Target Site in Desmoplakin

Desmoplakin (DSP) is a large (~260 kDa) protein found in the desmosome, a subcellular complex that links the cytoskeleton of one cell to its neighbor. A mutation ‘hot-spot’ within the NH<sub>2</sub>-terminal third of the DSP protein (specifically, residues 299–515) is associated with bot...

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Bibliographic Details
Main Authors: Catherine A. Hoover, Kendahl L. Ott, Heather R. Manring, Trevor Dew, Maegen A. Borzok, Nathan T. Wright
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Journal of Personalized Medicine
Subjects:
desmoplakin
molecular dynamics
calpain
arrhythmogenic cardiomyopathy
Online Access:https://www.mdpi.com/2075-4426/11/5/401

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