Administration of Interleukin-35-Conditioned Autologous Tolerogenic Dendritic Cells Prolong Allograft Survival After Heart Transplantation

Administration of Interleukin-35-Conditioned Autologous Tolerogenic Dendritic Cells Prolong Allograft Survival After Heart Transplantation

Background/Aims: IL-35, a powerful suppressor of inflammation and autoimmunity, is primarily secreted by regulatory T cells (Tregs) and can, in turn, promote Treg differentiation. However, the precise effect of IL-35 on dendritic cells (DCs) remains to be clarified. Methods: In this study, we invest...

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Bibliographic Details
Main Authors: Xianglan Liu, Yong Sun, Yang Zheng, Maomao Zhang, Xiangyuan Jin, Kai Kang, Yongshun Wang, Shuang Li, Hanlu Zhang, Qi Zhao, Shengnan Zhang, Jian Wu, Bo Yu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Interleukin-35
Dendritic cells
Regulatory T cells
Let-7i
Transplant immunity
Online Access:https://www.karger.com/Article/FullText/493298

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