Posterior Reversible Leukoencephalopathy Syndrome in a Patient after Acute COVID-19 Infection

Posterior Reversible Leukoencephalopathy Syndrome in a Patient after Acute COVID-19 Infection

A 90-year-old African American female with multiple comorbidities and a severe COVID-19 infection was discharged home in stable condition after two weeks of hospitalization. A week later, she developed new-onset generalized tonic-clonic seizures requiring readmission to the hospital. The patient’s c...

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Main Authors: Ketino Kobaidze, Yoo Mee Shin, Mariam Japaridze, Ioannis Karakis, Xin Wu
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:Case Reports in Neurological Medicine
Online Access:http://dx.doi.org/10.1155/2021/5564802
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spelling doaj-d4e8d71999a340979abb6f99afe3d4032021-05-10T00:26:28ZengHindawi LimitedCase Reports in Neurological Medicine2090-66762021-01-01202110.1155/2021/5564802Posterior Reversible Leukoencephalopathy Syndrome in a Patient after Acute COVID-19 InfectionKetino Kobaidze0Yoo Mee Shin1Mariam Japaridze2Ioannis Karakis3Xin Wu4Associate Professor of MedicineDivision of Hospital MedicineRoss University School of MedicineDepartment of NeurologyDepartment of Radiology and Imaging ScienceA 90-year-old African American female with multiple comorbidities and a severe COVID-19 infection was discharged home in stable condition after two weeks of hospitalization. A week later, she developed new-onset generalized tonic-clonic seizures requiring readmission to the hospital. The patient’s clinical course and brain imaging supported PRES. Her mentation returned to baseline with supportive care and anticonvulsant treatment. Follow-up brain MRI four months later demonstrated resolution of FLAIR signal abnormalities confirming PRES. SARS-CoV-2 insult on the cerebrovascular endothelial cells likely continued and despite the clinical recovery eventually resulted in PRES. We believe that this is the first case describing the presentation of PRES after recovery from severe acute COVID-19 infection.http://dx.doi.org/10.1155/2021/5564802
collection DOAJ
language English
format Article
sources DOAJ
author Ketino Kobaidze
Yoo Mee Shin
Mariam Japaridze
Ioannis Karakis
Xin Wu
spellingShingle Ketino Kobaidze
Yoo Mee Shin
Mariam Japaridze
Ioannis Karakis
Xin Wu
Posterior Reversible Leukoencephalopathy Syndrome in a Patient after Acute COVID-19 Infection
Case Reports in Neurological Medicine
author_facet Ketino Kobaidze
Yoo Mee Shin
Mariam Japaridze
Ioannis Karakis
Xin Wu
author_sort Ketino Kobaidze
title Posterior Reversible Leukoencephalopathy Syndrome in a Patient after Acute COVID-19 Infection
title_short Posterior Reversible Leukoencephalopathy Syndrome in a Patient after Acute COVID-19 Infection
title_full Posterior Reversible Leukoencephalopathy Syndrome in a Patient after Acute COVID-19 Infection
title_fullStr Posterior Reversible Leukoencephalopathy Syndrome in a Patient after Acute COVID-19 Infection
title_full_unstemmed Posterior Reversible Leukoencephalopathy Syndrome in a Patient after Acute COVID-19 Infection
title_sort posterior reversible leukoencephalopathy syndrome in a patient after acute covid-19 infection
publisher Hindawi Limited
series Case Reports in Neurological Medicine
issn 2090-6676
publishDate 2021-01-01
description A 90-year-old African American female with multiple comorbidities and a severe COVID-19 infection was discharged home in stable condition after two weeks of hospitalization. A week later, she developed new-onset generalized tonic-clonic seizures requiring readmission to the hospital. The patient’s clinical course and brain imaging supported PRES. Her mentation returned to baseline with supportive care and anticonvulsant treatment. Follow-up brain MRI four months later demonstrated resolution of FLAIR signal abnormalities confirming PRES. SARS-CoV-2 insult on the cerebrovascular endothelial cells likely continued and despite the clinical recovery eventually resulted in PRES. We believe that this is the first case describing the presentation of PRES after recovery from severe acute COVID-19 infection.
url http://dx.doi.org/10.1155/2021/5564802
work_keys_str_mv AT ketinokobaidze posteriorreversibleleukoencephalopathysyndromeinapatientafteracutecovid19infection
AT yoomeeshin posteriorreversibleleukoencephalopathysyndromeinapatientafteracutecovid19infection
AT mariamjaparidze posteriorreversibleleukoencephalopathysyndromeinapatientafteracutecovid19infection
AT ioanniskarakis posteriorreversibleleukoencephalopathysyndromeinapatientafteracutecovid19infection
AT xinwu posteriorreversibleleukoencephalopathysyndromeinapatientafteracutecovid19infection
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