Pore Morphology Effects on the Fibrovascular Tissue Growth in Porous Polymer Substrates

Pore Morphology Effects on the Fibrovascular Tissue Growth in Porous Polymer Substrates

The feasibility of developing biodegradable polymer scaffolds to engineer tissues was investigated by studying the effects of pore size on the dynamics of fibrovascular tissue ingrowth. Tissue advanced into amorphous poly(l-lactic acid) porous substrates faster as the pore diameter increased. Porous...

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Main Authors: M. Conley Wake, Charles W. Patrick, Antonios G. Mikos
Format: Article
Language:English
Published: SAGE Publishing 1994-07-01
Series:Cell Transplantation
Online Access:https://doi.org/10.1177/096368979400300411
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spelling doaj-d4e30a3c8a6c4b0bb7463ea31aca22402020-11-25T03:52:03ZengSAGE PublishingCell Transplantation0963-68971555-38921994-07-01310.1177/096368979400300411Pore Morphology Effects on the Fibrovascular Tissue Growth in Porous Polymer SubstratesM. Conley Wake0Charles W. Patrick1Antonios G. Mikos2Department of Chemical Engineering and Institute of Biosciences and Bioengineering, Cox Laboratory for Biomedical Engineering, Rice University, P.O. Box 1892, Houston, TX 77251, USADepartment of Chemical Engineering and Institute of Biosciences and Bioengineering, Cox Laboratory for Biomedical Engineering, Rice University, P.O. Box 1892, Houston, TX 77251, USADepartment of Chemical Engineering and Institute of Biosciences and Bioengineering, Cox Laboratory for Biomedical Engineering, Rice University, P.O. Box 1892, Houston, TX 77251, USAThe feasibility of developing biodegradable polymer scaffolds to engineer tissues was investigated by studying the effects of pore size on the dynamics of fibrovascular tissue ingrowth. Tissue advanced into amorphous poly(l-lactic acid) porous substrates faster as the pore diameter increased. Porous cylindrical devices of 13.5 mm diameter, 5 mm thickness, and approximately 500 μm pore size were filled completely by tissue 5 days postimplantation. Although prevascularized devices possessed minimal void volume for cell seeding to regenerate metabolic organs, they hold promise in the regeneration of tubular tissues by relying on the epithelization of prevascularized grafts.https://doi.org/10.1177/096368979400300411
collection DOAJ
language English
format Article
sources DOAJ
author M. Conley Wake
Charles W. Patrick
Antonios G. Mikos
spellingShingle M. Conley Wake
Charles W. Patrick
Antonios G. Mikos
Pore Morphology Effects on the Fibrovascular Tissue Growth in Porous Polymer Substrates
Cell Transplantation
author_facet M. Conley Wake
Charles W. Patrick
Antonios G. Mikos
author_sort M. Conley Wake
title Pore Morphology Effects on the Fibrovascular Tissue Growth in Porous Polymer Substrates
title_short Pore Morphology Effects on the Fibrovascular Tissue Growth in Porous Polymer Substrates
title_full Pore Morphology Effects on the Fibrovascular Tissue Growth in Porous Polymer Substrates
title_fullStr Pore Morphology Effects on the Fibrovascular Tissue Growth in Porous Polymer Substrates
title_full_unstemmed Pore Morphology Effects on the Fibrovascular Tissue Growth in Porous Polymer Substrates
title_sort pore morphology effects on the fibrovascular tissue growth in porous polymer substrates
publisher SAGE Publishing
series Cell Transplantation
issn 0963-6897
1555-3892
publishDate 1994-07-01
description The feasibility of developing biodegradable polymer scaffolds to engineer tissues was investigated by studying the effects of pore size on the dynamics of fibrovascular tissue ingrowth. Tissue advanced into amorphous poly(l-lactic acid) porous substrates faster as the pore diameter increased. Porous cylindrical devices of 13.5 mm diameter, 5 mm thickness, and approximately 500 μm pore size were filled completely by tissue 5 days postimplantation. Although prevascularized devices possessed minimal void volume for cell seeding to regenerate metabolic organs, they hold promise in the regeneration of tubular tissues by relying on the epithelization of prevascularized grafts.
url https://doi.org/10.1177/096368979400300411
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AT charleswpatrick poremorphologyeffectsonthefibrovasculartissuegrowthinporouspolymersubstrates
AT antoniosgmikos poremorphologyeffectsonthefibrovasculartissuegrowthinporouspolymersubstrates
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