Synthesis, characterization, and antibacterial studies of pipemidic acid metal complexes

• Main Authors: Ahsan Zamir Siddiqi, Agha Zeeshan Mirza
• Format: Article
• Language: English
• Published: SpringerOpen 2021-07-01
• Series: Future Journal of Pharmaceutical Sciences
• Subjects: Pipemidic acid; Metal complexes; Antibacterial studies
• Online Access: https://doi.org/10.1186/s43094-021-00301-8

Abstract Background Pipemidic acid, like other quinolones, is susceptible against different organisms in vitro, and it was proved to be a preferred choice for certain indications. Previous studies reveal that concurrent administration of essential and trace elements with quinolones decreases gastrointestinal absorption, causing therapeutic failure. To study the probable interaction of pipemidic acid with essential and trace elements present in the human body, pipemidic acid has been reacted with magnesium, calcium, chromium, manganese, iron, cobalt, nickel, copper, zinc, and cadmium, the complexes formed. Results The compounds were characterized by the melting point, conductance studies, IR, UV, 1H-NMR, CHN, and atomic absorption analysis. Conclusion The results suggested oxygen atoms present at carbonyl and carboxylic group render the bidentate6 property to the pipemidic acid. The antimicrobial activity of the compounds was determined by the disk diffusion method, and both standard and complexes show no antibacterial activity against the clinical isolates.