Correlative light electron ion microscopy reveals in vivo localisation of bedaquiline in Mycobacterium tuberculosis-infected lungs.
Correlative light, electron, and ion microscopy (CLEIM) offers huge potential to track the intracellular fate of antibiotics, with organelle-level resolution. However, a correlative approach that enables subcellular antibiotic visualisation in pathogen-infected tissue is lacking. Here, we developed...
Main Authors: | Antony Fearns, Daniel J Greenwood, Angela Rodgers, Haibo Jiang, Maximiliano G Gutierrez |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2020-12-01
|
Series: | PLoS Biology |
Online Access: | https://doi.org/10.1371/journal.pbio.3000879 |
Similar Items
-
Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide
by: Pierre Santucci, et al.
Published: (2021-06-01) -
Acquired resistance of Mycobacterium tuberculosis to bedaquiline.
by: Koen Andries, et al.
Published: (2014-01-01) -
Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis
by: Jared S. Mackenzie, et al.
Published: (2020-11-01) -
Prevalence of Mycobacterium tuberculosis resistant to bedaquiline and delamanid in China
by: Wencong He, et al.
Published: (2021-09-01) -
atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure
by: Aubry, A., et al.
Published: (2022)