Immunotherapy in Non-Small Cell Lung Cancer: Shifting Prognostic Paradigms

Immune checkpoint inhibitors have shown efficacy in the treatment of non-small cell lung cancer (NSCLC) in the adjuvant, first- and subsequent-line settings. In metastatic disease, they provide hope of durable response where “best-case” scenario has long been inadequate. This pro...

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Main Authors:	Megan B. Barnet, Wendy A. Cooper, Michael J. Boyer, Steven Kao
Format:	Article
Language:	English
Published:	MDPI AG 2018-06-01
Series:	Journal of Clinical Medicine
Subjects:	non-small cell lung cancer immunotherapy checkpoint inhibitors
Online Access:	http://www.mdpi.com/2077-0383/7/6/151

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spelling	doaj-d4cdd1e874ae4276bd67fcd9dd9894702020-11-25T02:41:36ZengMDPI AGJournal of Clinical Medicine2077-03832018-06-017615110.3390/jcm7060151jcm7060151Immunotherapy in Non-Small Cell Lung Cancer: Shifting Prognostic ParadigmsMegan B. Barnet0Wendy A. Cooper1Michael J. Boyer2Steven Kao3The Garvan Institute of Medical Research, Darlinghurst, NSW 2010, AustraliaSydney Medical School, The University of Sydney, Camperdown, NSW 2006, AustraliaSydney Medical School, The University of Sydney, Camperdown, NSW 2006, AustraliaSydney Medical School, The University of Sydney, Camperdown, NSW 2006, AustraliaImmune checkpoint inhibitors have shown efficacy in the treatment of non-small cell lung cancer (NSCLC) in the adjuvant, first- and subsequent-line settings. In metastatic disease, they provide hope of durable response where “best-case” scenario has long been inadequate. This progress has highlighted the immunogenic nature of NSCLC and invigorated research into immunotherapy in the field. In this review we consider the foundations of immunotherapy in NSCLC, canvass the current research and summarise the evidence guiding clinical practice.http://www.mdpi.com/2077-0383/7/6/151non-small cell lung cancerimmunotherapycheckpoint inhibitors
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Megan B. Barnet Wendy A. Cooper Michael J. Boyer Steven Kao
spellingShingle	Megan B. Barnet Wendy A. Cooper Michael J. Boyer Steven Kao Immunotherapy in Non-Small Cell Lung Cancer: Shifting Prognostic Paradigms Journal of Clinical Medicine non-small cell lung cancer immunotherapy checkpoint inhibitors
author_facet	Megan B. Barnet Wendy A. Cooper Michael J. Boyer Steven Kao
author_sort	Megan B. Barnet
title	Immunotherapy in Non-Small Cell Lung Cancer: Shifting Prognostic Paradigms
title_short	Immunotherapy in Non-Small Cell Lung Cancer: Shifting Prognostic Paradigms
title_full	Immunotherapy in Non-Small Cell Lung Cancer: Shifting Prognostic Paradigms
title_fullStr	Immunotherapy in Non-Small Cell Lung Cancer: Shifting Prognostic Paradigms
title_full_unstemmed	Immunotherapy in Non-Small Cell Lung Cancer: Shifting Prognostic Paradigms
title_sort	immunotherapy in non-small cell lung cancer: shifting prognostic paradigms
publisher	MDPI AG
series	Journal of Clinical Medicine
issn	2077-0383
publishDate	2018-06-01
description	Immune checkpoint inhibitors have shown efficacy in the treatment of non-small cell lung cancer (NSCLC) in the adjuvant, first- and subsequent-line settings. In metastatic disease, they provide hope of durable response where “best-case” scenario has long been inadequate. This progress has highlighted the immunogenic nature of NSCLC and invigorated research into immunotherapy in the field. In this review we consider the foundations of immunotherapy in NSCLC, canvass the current research and summarise the evidence guiding clinical practice.
topic	non-small cell lung cancer immunotherapy checkpoint inhibitors
url	http://www.mdpi.com/2077-0383/7/6/151
work_keys_str_mv	AT meganbbarnet immunotherapyinnonsmallcelllungcancershiftingprognosticparadigms AT wendyacooper immunotherapyinnonsmallcelllungcancershiftingprognosticparadigms AT michaeljboyer immunotherapyinnonsmallcelllungcancershiftingprognosticparadigms AT stevenkao immunotherapyinnonsmallcelllungcancershiftingprognosticparadigms
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Immunotherapy in Non-Small Cell Lung Cancer: Shifting Prognostic Paradigms

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