Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice

Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice

Objective: Maintenance of glucose homeostasis requires the precise regulation of hormone secretion from the endocrine pancreas. Free fatty acid receptor 4 (FFAR4/GPR120) is a G protein-coupled receptor whose activation in islets of Langerhans promotes insulin and glucagon secretion and inhibits soma...

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Bibliographic Details
Main Authors: Marine L. Croze, Marcus F. Flisher, Arthur Guillaume, Caroline Tremblay, Glyn M. Noguchi, Sabrina Granziera, Kevin Vivot, Vincent C. Castillo, Scott A. Campbell, Julien Ghislain, Mark O. Huising, Vincent Poitout
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Metabolism
Subjects:
FFAR4
GPR120
Somatostatin
Insulin
Glucagon
Islet of langerhans
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821000065

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http://www.sciencedirect.com/science/article/pii/S2212877821000065

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