CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer

Dormancy of disseminated cancer cells has been described in patients with breast cancer and associated with late metastatic relapses. Here the authors show that CD39+PD-1+CD8+ T cells correlate with increased disease free survival post-resection in breast cancer patients, and promote dormancy in a p...

Full description

Bibliographic Details
Main Authors:	Paulino Tallón de Lara, Héctor Castañón, Marijne Vermeer, Nicolás Núñez, Karina Silina, Bettina Sobottka, Joaquín Urdinez, Virginia Cecconi, Hideo Yagita, Farkhondeh Movahedian Attar, Stefanie Hiltbrunner, Isabelle Glarner, Holger Moch, Sònia Tugues, Burkhard Becher, Maries van den Broek
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-21045-2

id	doaj-d4c93583ff8e4ff4b53a6a528ca96962
record_format	Article
spelling	doaj-d4c93583ff8e4ff4b53a6a528ca969622021-02-07T12:12:30ZengNature Publishing GroupNature Communications2041-17232021-02-0112111410.1038/s41467-021-21045-2CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancerPaulino Tallón de Lara0Héctor Castañón1Marijne Vermeer2Nicolás Núñez3Karina Silina4Bettina Sobottka5Joaquín Urdinez6Virginia Cecconi7Hideo Yagita8Farkhondeh Movahedian Attar9Stefanie Hiltbrunner10Isabelle Glarner11Holger Moch12Sònia Tugues13Burkhard Becher14Maries van den Broek15Institute of Experimental Immunology, University of ZurichInstitute of Experimental Immunology, University of ZurichInstitute of Experimental Immunology, University of ZurichInstitute of Experimental Immunology, University of ZurichInstitute of Experimental Immunology, University of ZurichDepartment of Pathology and Molecular Pathology, University Hospital ZurichDepartment of Orthopaedics, Balgrist University Hospital, University of ZurichInstitute of Experimental Immunology, University of ZurichDepartment of Immunology, Juntendo University School of MedicineInstitute of Experimental Immunology, University of ZurichInstitute of Experimental Immunology, University of ZurichInstitute of Experimental Immunology, University of ZurichComprehensive Cancer Center ZurichInstitute of Experimental Immunology, University of ZurichInstitute of Experimental Immunology, University of ZurichInstitute of Experimental Immunology, University of ZurichDormancy of disseminated cancer cells has been described in patients with breast cancer and associated with late metastatic relapses. Here the authors show that CD39+PD-1+CD8+ T cells correlate with increased disease free survival post-resection in breast cancer patients, and promote dormancy in a preclinical model.https://doi.org/10.1038/s41467-021-21045-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Paulino Tallón de Lara Héctor Castañón Marijne Vermeer Nicolás Núñez Karina Silina Bettina Sobottka Joaquín Urdinez Virginia Cecconi Hideo Yagita Farkhondeh Movahedian Attar Stefanie Hiltbrunner Isabelle Glarner Holger Moch Sònia Tugues Burkhard Becher Maries van den Broek
spellingShingle	Paulino Tallón de Lara Héctor Castañón Marijne Vermeer Nicolás Núñez Karina Silina Bettina Sobottka Joaquín Urdinez Virginia Cecconi Hideo Yagita Farkhondeh Movahedian Attar Stefanie Hiltbrunner Isabelle Glarner Holger Moch Sònia Tugues Burkhard Becher Maries van den Broek CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer Nature Communications
author_facet	Paulino Tallón de Lara Héctor Castañón Marijne Vermeer Nicolás Núñez Karina Silina Bettina Sobottka Joaquín Urdinez Virginia Cecconi Hideo Yagita Farkhondeh Movahedian Attar Stefanie Hiltbrunner Isabelle Glarner Holger Moch Sònia Tugues Burkhard Becher Maries van den Broek
author_sort	Paulino Tallón de Lara
title	CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer
title_short	CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer
title_full	CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer
title_fullStr	CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer
title_full_unstemmed	CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer
title_sort	cd39+pd-1+cd8+ t cells mediate metastatic dormancy in breast cancer
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-02-01
description	Dormancy of disseminated cancer cells has been described in patients with breast cancer and associated with late metastatic relapses. Here the authors show that CD39+PD-1+CD8+ T cells correlate with increased disease free survival post-resection in breast cancer patients, and promote dormancy in a preclinical model.
url	https://doi.org/10.1038/s41467-021-21045-2
work_keys_str_mv	AT paulinotallondelara cd39pd1cd8tcellsmediatemetastaticdormancyinbreastcancer AT hectorcastanon cd39pd1cd8tcellsmediatemetastaticdormancyinbreastcancer AT marijnevermeer cd39pd1cd8tcellsmediatemetastaticdormancyinbreastcancer AT nicolasnunez cd39pd1cd8tcellsmediatemetastaticdormancyinbreastcancer AT karinasilina cd39pd1cd8tcellsmediatemetastaticdormancyinbreastcancer AT bettinasobottka cd39pd1cd8tcellsmediatemetastaticdormancyinbreastcancer AT joaquinurdinez cd39pd1cd8tcellsmediatemetastaticdormancyinbreastcancer AT virginiacecconi cd39pd1cd8tcellsmediatemetastaticdormancyinbreastcancer AT hideoyagita cd39pd1cd8tcellsmediatemetastaticdormancyinbreastcancer AT farkhondehmovahedianattar cd39pd1cd8tcellsmediatemetastaticdormancyinbreastcancer AT stefaniehiltbrunner cd39pd1cd8tcellsmediatemetastaticdormancyinbreastcancer AT isabelleglarner cd39pd1cd8tcellsmediatemetastaticdormancyinbreastcancer AT holgermoch cd39pd1cd8tcellsmediatemetastaticdormancyinbreastcancer AT soniatugues cd39pd1cd8tcellsmediatemetastaticdormancyinbreastcancer AT burkhardbecher cd39pd1cd8tcellsmediatemetastaticdormancyinbreastcancer AT mariesvandenbroek cd39pd1cd8tcellsmediatemetastaticdormancyinbreastcancer
_version_	1724281614224064512

CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer

Similar Items