Effect of in vivo Hydroxychloroquine and ex vivo Anti-BDCA2 mAb Treatment on pDC IFNα Production From Patients Affected With Cutaneous Lupus Erythematosus

Effect of in vivo Hydroxychloroquine and ex vivo Anti-BDCA2 mAb Treatment on pDC IFNα Production From Patients Affected With Cutaneous Lupus Erythematosus

Objective: Plasmacytoid dendritic cells (pDCs) are a major source of Type-I Interferon (IFN-I), a key driver in cutaneous lupus erythematosus (CLE). Currently evaluated in Phase II clinical trial, 24F4A (BIIB059) is an antibody targeting BDCA2, an inhibitory receptor expressed on pDCs. Given that Hy...

Full description

Bibliographic Details
Main Authors:	Agnes Gardet, Alex Pellerin, Christie-Ann McCarl, Rohan Diwanji, Wenting Wang, Douglas Donaldson, Nathalie Franchimont, Victoria P. Werth, Dania Rabah
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-02-01
Series:	Frontiers in Immunology
Subjects:	cutaneous lupus erythematosus (CLE) hydroxychloroquine interferon systemic lupus erythematosus (SLE) BDCA2 blood dendritic cell antigen 2 toll like receptor (TLR)
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2019.00275/full

Similar Items

Evaluation of Hydroxychloroquine Blood Concentrations and Effects in Childhood-Onset Systemic Lupus Erythematosus
by: Noël Zahr, et al.
Published: (2021-03-01)

New onset bullous lupus erythematosus in a systemic lupus erythematosus patient after initiation of hydroxychloroquin
by: Chanchal Gera, et al.
Published: (2014-01-01)

Highly selective inhibition of Bruton’s tyrosine kinase attenuates skin and brain disease in murine lupus
by: Samantha A. Chalmers, et al.
Published: (2018-01-01)

Evaluation of the mortality in systemic Lupus erythematosis (SLE): Analysis of 2021 patients
by: Gharibdoost F, et al.
Published: (2003-03-01)

Evaluation of the mortality in systemic Lupus erythematosis (SLE): Analysis of 2021 patients
by: Gharibdoost F, et al.
Published: (2003-05-01)

Lupus tumidus
by: Julia Nowowiejska, et al.
Published: (2020-02-01)

Laporan Kasus Cutaneus Discoid Lupus Erythematosus
by: Sarah Yunara, et al.
Published: (2017-01-01)

A case of hyperpigmentation induced by hydroxychloroquine and quinacrine in a patient with systemic lupus erythematosus and review of the literature
by: Daniel Kwak, et al.
Published: (2020-09-01)

Multi-voxel proton magnetic resonance spectroscopy changes in neuropsychiatric lupus patients
by: Page l. Wang, et al.
Published: (2016-06-01)

Hydroxychloroquine levels in patients with systemic lupus erythematosus: whole blood is preferable but serum levels also detect non-adherence
by: Benoit Blanchet, et al.
Published: (2020-09-01)

Direct immunofluorescence in Lupus Erythematosus (LE)
by: Roseli Svartman Isfer, et al.

The place of hydroxychloroquine in modern dermatology
by: Aleksandra Dańczak-Pazdrowska, et al.
Published: (2021-08-01)

Hydroxychloroquine decreases Th17-related cytokines in systemic lupus erythematosus and rheumatoid arthritis patients
by: Juliana Cruz da Silva, et al.
Published: (2013-06-01)

The Effect of Hydroxychloroquine Treatment on Blood Sugar Level, Serum Lipid Profile and the Retina in Systemic Lupus Erythematosus Patients
by: Rania M. Sarhan, et al.
Published: (2016-03-01)

Hydroxychloroquine Does Not Increase the Risk of Cardiac Arrhythmia in Common Rheumatic Diseases: A Nationwide Population-Based Cohort Study
by: Chien-Hsien Lo, et al.
Published: (2021-04-01)

Hydroxychloroquine inhibits CD154 expression in CD4+ T lymphocytes of systemic lupus erythematosus through NFAT, but not STAT5, signaling
by: Shu-Fen Wu, et al.
Published: (2017-08-01)

Perawatan Periodontal pada Pasien Lupus Eritematosus Sistemik
by: Nur Rahma Prihantini, et al.
Published: (2012-06-01)

Prevalence and clinical correlates of antiphospholipid antibodies in South Africans with systemic lupus erythematosus
by: Gould, Trevor John
Published: (2008)

Systemic lupus Erythematosus activity and Hydroxychloroquine use before and after end-stage renal disease
by: Maria Salgado Guerrero, et al.
Published: (2020-10-01)

Lupus panniculitis as an initial manifestation of systemic lupus erythematosus
by: Patel Raksha, et al.
Published: (2010-01-01)

Association of Social Support and the Well-being of Patients with Systemic Lupus Erythematosus: Analysis of the Georgians Organized Against Lupus (GOAL) Cohort Study
by: Gooden, Reginald O.
Published: (2015)

Cutaneous lupus erythematosus: An update
by: Carina M Grönhagen, et al.
Published: (2014-01-01)

Effects of methotrexate combined with hydroxychloroquine sulfate and prednisone acetate on inflammatory response, immune function and liver and renal function in patients with systemic lupus erythematosus
by: Jiang-Li Xia, et al.
Published: (2017-11-01)

Lupus Enteritis: An Uncommon Manifestation of Systemic Lupus Erythematosus as an Initial Presentation
by: Vishal Bodh, et al.
Published: (2017-07-01)

Incidence of COVID-19 Hospitalisation in Patients with Systemic Lupus Erythematosus: A Nationwide Cohort Study from Denmark
by: René Cordtz, et al.
Published: (2021-08-01)

A Case of Heart Failure in a Patient With Systemic Lupus Erythematosus
by: Heriberto Matos Santana, MD, et al.
Published: (2020-03-01)

Intestinal microbiota and active systemic lupus erythematosus: a systematic review
by: Juliana Rosa Pires Vieira, et al.
Published: (2021-07-01)

Integrated care process for systemic lupus erythematosus: towards quality in healthcare
by: Sofia Carvalho Barreira, et al.
Published: (2020-10-01)

Systemic lupus erythematosus in men: difficulties of diagnosis and specific features of clinical picture
by: Nataliya Gennad'evna Klyukvina, et al.
Published: (2011-05-01)

Glomerulopatía colapsante en lupus eritematoso sistémico con respuesta positiva a tratamiento con mofetil micofenolato
by: Araceli Chico Capote, et al.

Assessment of Serum Thrombomodulin in Patients with Systemic Lupus Erythematosus in Rheumatology Research Center
by: Akbarian Mahmood, et al.
Published: (2009-05-01)

A rare case of laparoscopy towards SLE with lupus mesenteric vasculitis induced ascites
by: Kamleshsingh Shadhu, et al.
Published: (2019-07-01)

Correlation Between Steroid Therapy and Lipid Profile in Systemic Lupus Erythematosus Patients
by: Atik N, et al.
Published: (2020-03-01)

Assessment of Serum Thrombomodulin in Patients with Systemic Lupus Erythematosus in Rheumatology Research Center
by: Mahmood Akbarian, et al.
Published: (2009-04-01)

Successful treatment with belimumab of severe systemic lupus erythematosus not responding to standard therapy: a case report
by: Ottavia Magnani, et al.
Published: (2016-03-01)

Advances in Epigenetics and Integration of Omics in Lupus
by: Joyce S. Hui-Yuen, et al.
Published: (2017-08-01)

Low incidence of intrauterine growth restriction in pregnant patients with systemic lupus erythematosus taking hydroxychloroquine
by: Valentina Canti, et al.
Published: (2021-07-01)

Laboratory and Neuroimaging Biomarkers in Neuropsychiatric Systemic Lupus Erythematosus: Where Do We Stand, Where To Go?
by: César Magro-Checa, et al.
Published: (2018-12-01)

Managing active iupus nephritis during COVID-19 pandemic
by: Joyita Bharati, et al.
Published: (2021-01-01)

A meta-analysis of public microarray data identifies gene regulatory pathways deregulated in peripheral blood mononuclear cells from individuals with Systemic Lupus Erythematosus compared to those without
by: Wendy Kröger, et al.
Published: (2016-11-01)