Glycosylation Pattern and in vitro Bioactivity of Reference Follitropin alfa and Biosimilars

Glycosylation Pattern and in vitro Bioactivity of Reference Follitropin alfa and Biosimilars

Recombinant follicle-stimulating hormone (FSH) (follitropin alfa) and biosimilar preparations are available for clinical use. They have specific FSH activity and a unique glycosylation profile dependent on source cells. The aim of the study is to compare the originator (reference) follitropin alfa (...

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Bibliographic Details
Main Authors: Laura Riccetti, Samantha Sperduti, Clara Lazzaretti, Danièle Klett, Francesco De Pascali, Elia Paradiso, Silvia Limoncella, Francesco Potì, Simonetta Tagliavini, Tommaso Trenti, Eugenio Galano, Angelo Palmese, Abhijeet Satwekar, Jessica Daolio, Alessia Nicoli, Maria Teresa Villani, Lorenzo Aguzzoli, Eric Reiter, Manuela Simoni, Livio Casarini
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Endocrinology
Subjects:
FSH
biosimilar
gonal-F
bemfola
ovaleap
glycosylation
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00503/full

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