THE EFFECTS OF ACUTE MILD HYPOBARIC HYPOXIA ON OLD RATS’ MYOCARDIAL LEFT VENTRICLE OXIDATIVE DAMAGE

THE EFFECTS OF ACUTE MILD HYPOBARIC HYPOXIA ON OLD RATS’ MYOCARDIAL LEFT VENTRICLE OXIDATIVE DAMAGE

Oxidative damage may occur during hypoxia. Under hypoxic conditions, elderly have weaker defense against oxidative damage. The present study aims to examine the effects of acute mild-strength hypobaric hypoxia on aged rats’ myocardial left ventricle oxidative damage. In the study, 24 months’ old Wis...

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Main Author: Eda AĞAŞÇIOĞLU
Format: Article
Language:English
Published: Turkish Sports Medicine Association 2015-12-01
Series:Spor Hekimligi Dergisi
Subjects:
High altitude
free radicals
damage indicators
heart muscle
elder
Wistar albino rats
Online Access: http://journalofsportsmedicine.org/eng/full-text/209/tur
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spelling doaj-d4a701ecfe684c6cac7d8a9e698ed2b22020-11-24T22:42:34ZengTurkish Sports Medicine AssociationSpor Hekimligi Dergisi1300-05512587-14982015-12-01504175184209THE EFFECTS OF ACUTE MILD HYPOBARIC HYPOXIA ON OLD RATS’ MYOCARDIAL LEFT VENTRICLE OXIDATIVE DAMAGEEda AĞAŞÇIOĞLU0 Çankaya Üniversitesi, Sosyal Bilimler Enstitüsü, Ankara Oxidative damage may occur during hypoxia. Under hypoxic conditions, elderly have weaker defense against oxidative damage. The present study aims to examine the effects of acute mild-strength hypobaric hypoxia on aged rats’ myocardial left ventricle oxidative damage. In the study, 24 months’ old Wistar albino rats were used. Following six hours of exposure to 6000 m altitude, heart muscles’ radical damage indicators, i.e. lipid hydroperoxides, protein carbonyl, advanced oxidation protein products, total thiol and protein thiol levels were measured. Both protein carbonyl and lipid hydroperoxide levels in old rats’ heart muscle left ventricles were found to be significantly higher (p http://journalofsportsmedicine.org/eng/full-text/209/tur High altitudefree radicalsdamage indicatorsheart muscleelderWistar albino rats
collection DOAJ
language English
format Article
sources DOAJ
author Eda AĞAŞÇIOĞLU
spellingShingle Eda AĞAŞÇIOĞLU
THE EFFECTS OF ACUTE MILD HYPOBARIC HYPOXIA ON OLD RATS’ MYOCARDIAL LEFT VENTRICLE OXIDATIVE DAMAGE
Spor Hekimligi Dergisi
High altitude
free radicals
damage indicators
heart muscle
elder
Wistar albino rats
author_facet Eda AĞAŞÇIOĞLU
author_sort Eda AĞAŞÇIOĞLU
title THE EFFECTS OF ACUTE MILD HYPOBARIC HYPOXIA ON OLD RATS’ MYOCARDIAL LEFT VENTRICLE OXIDATIVE DAMAGE
title_short THE EFFECTS OF ACUTE MILD HYPOBARIC HYPOXIA ON OLD RATS’ MYOCARDIAL LEFT VENTRICLE OXIDATIVE DAMAGE
title_full THE EFFECTS OF ACUTE MILD HYPOBARIC HYPOXIA ON OLD RATS’ MYOCARDIAL LEFT VENTRICLE OXIDATIVE DAMAGE
title_fullStr THE EFFECTS OF ACUTE MILD HYPOBARIC HYPOXIA ON OLD RATS’ MYOCARDIAL LEFT VENTRICLE OXIDATIVE DAMAGE
title_full_unstemmed THE EFFECTS OF ACUTE MILD HYPOBARIC HYPOXIA ON OLD RATS’ MYOCARDIAL LEFT VENTRICLE OXIDATIVE DAMAGE
title_sort effects of acute mild hypobaric hypoxia on old rats’ myocardial left ventricle oxidative damage
publisher Turkish Sports Medicine Association
series Spor Hekimligi Dergisi
issn 1300-0551
2587-1498
publishDate 2015-12-01
description Oxidative damage may occur during hypoxia. Under hypoxic conditions, elderly have weaker defense against oxidative damage. The present study aims to examine the effects of acute mild-strength hypobaric hypoxia on aged rats’ myocardial left ventricle oxidative damage. In the study, 24 months’ old Wistar albino rats were used. Following six hours of exposure to 6000 m altitude, heart muscles’ radical damage indicators, i.e. lipid hydroperoxides, protein carbonyl, advanced oxidation protein products, total thiol and protein thiol levels were measured. Both protein carbonyl and lipid hydroperoxide levels in old rats’ heart muscle left ventricles were found to be significantly higher (p
topic High altitude
free radicals
damage indicators
heart muscle
elder
Wistar albino rats
url http://journalofsportsmedicine.org/eng/full-text/209/tur
work_keys_str_mv AT edaagascioglu theeffectsofacutemildhypobarichypoxiaonoldratsmyocardialleftventricleoxidativedamage
AT edaagascioglu effectsofacutemildhypobarichypoxiaonoldratsmyocardialleftventricleoxidativedamage
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