Luteolin Attenuates Allergic Nasal Inflammation via Inhibition of Interleukin-4 in an Allergic Rhinitis Mouse Model and Peripheral Blood From Human Subjects With Allergic Rhinitis

Luteolin Attenuates Allergic Nasal Inflammation via Inhibition of Interleukin-4 in an Allergic Rhinitis Mouse Model and Peripheral Blood From Human Subjects With Allergic Rhinitis

Objectives: Luteolin is the active component of Perilla frutescens, an herb for the treatment of allergy in Asia. In this study, we aimed to investigate the effects and mechanisms of luteolin treatment.Methods: BALB/c mice sensitized with house dust mite (HDM) to induce allergic rhinitis (AR), and t...

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Bibliographic Details
Main Authors: Kai-Li Liang, Sheng-Jie Yu, Wan-Chun Huang, Hung-Rong Yen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
allergic rhinitis
IL-4
luteolin
traditional Chinese medicine
type 2 helper T cells
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00291/full

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