Undifferentiated pleomorphic sarcoma presenting as a gingival mass: A rare case

• Main Authors: B S Sreenivasan, V Vinod Sankar, Deepu George Mathew, Merin George
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2015-01-01
• Series: Journal of Dr. NTR University of Health Sciences
• Subjects: Malignant fibrous histiocytoma; pan histiocytic marker; storiform pleomorphic; undifferentiated pleomorphic sarcoma
• Online Access: http://www.jdrntruhs.org/article.asp?issn=2277-8632;year=2015;volume=4;issue=2;spage=130;epage=133;aulast=Sreenivasan
• ISSN: 2277-8632

Malignant fibrous histiocytoma which was once considered as a tumor of adults, is now being re-classified and subtyped either as a pleomorphic undifferentiated sarcoma or pleomorphic variant of other spindle cell tumors. Only less than 5% of these cases are reported in the head and neck, and its presentation intra-orally is still rarer. Herein, we report a case of gingival swelling in relation to the 16 region, which on microscopic examination showed a histomorphometric pattern of storiform pleomorphic-malignant fibrous histiocytoma. Immunohistochemical studies were done to exclude similar appearing spindle cell neoplasms. The tumor showed focal positivity for pan histiocytic marker, CD68. Based on the histopathological and immunohistochemical profiles, the tumor was diagnosed as undifferentiated pleomorphic sarcoma.