Intra-Tumoral Delivery of IL-27 Using Adeno-Associated Virus Stimulates Anti-tumor Immunity and Enhances the Efficacy of Immunotherapy

Intra-Tumoral Delivery of IL-27 Using Adeno-Associated Virus Stimulates Anti-tumor Immunity and Enhances the Efficacy of Immunotherapy

IL-27 is an anti-inflammatory cytokine that has been shown to have potent anti-tumor activity. We recently reported that systemic delivery of IL-27 using recombinant adeno-associated virus (rAAV) induced depletion of Tregs and significantly enhanced the efficacy of cancer immunotherapy in a variety...

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Bibliographic Details
Main Authors: Aiyan Hu, Miao Ding, Jianmin Zhu, Jin-Qing Liu, Xueliang Pan, Kalpana Ghoshal, Xue-Feng Bai
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
IL-27
recombinant adeno-associated virus
B16 melanoma
J558 plasmacytoma
Tregs
PD-1 blockade therapy
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00210/full

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