| Summary: | To define structural and functional changes of skin in women of different age groups and their relationships in this work intraoperational biopsy material of skin of 100 women at the age from 19 to 73 years, that was taken during standard surgery instrumentations for different defects of face and neck skin correction, was investigated. Skin material of cheek face region, temple region of head and anterior neck region was morphologically processed. To define parameters of microvessels and dermal fibroblasts, thickness of epidermis, serial sections was investigated with the help of morphometry. The range of skin hydratation was investigated with the help of Doppler and ultrasound techniques. It was determined, that involution dynamic of microvessel condition in papillary layer of derma coincides with grade reduction of relative volume of microvesseles bed, that was observed in greatest part in cheek region of face. There is growth of relative microvesseles volume in reticular layer of derma in women of older age groups. Microcirculation age changes include structural disorders of intrapapillary capillary loops, disorganization of arterioles in papillary and reticular layers of derma, disorders of venules because of the changes in microenvironmental fibrillar network. Essential structural and functional changes observed in skin of cheek region in women of 33-40 years and in temple region of head and anterior neck region in women of 41-50 years. It accompanied with thinning of epidermis and emergence of keratinocytes with defective tinctorial properties and also grade reduction in quantitative density of fibroblasts and limitation of their functional activity. There is essential correlation between quantitative parameters of microcirculation and marks of age dynamic of epidermis condition and range of skin hydratation.
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