Renal targeting of captopril using captopril-lysozyme conjugate enhances its antiproteinuric effect in adriamycin-induced nephrosis

Renal targeting of captopril using captopril-lysozyme conjugate enhances its antiproteinuric effect in adriamycin-induced nephrosis

Introduction High-sodium intake blunts the renoprotective efficacy of angiotensin-converting enzyme (ACE) inhibitors. We investigated whether targeting the drug to the kidneys may attenuate the inferior response to ACE inhibitor (ACE-I) under high-sodium conditions. The ACE-I, captopril, was coupled...

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Bibliographic Details
Main Authors: Willemijn AKM Windt, Jai Prakash, Robbert Jan Kok, Frits Moolenaar, C Alex Kluppel, Dick de Zeeuw, Richard PE van Dokkum, Robert H Henning
Format: Article
Language:English
Published: Hindawi - SAGE Publishing 2004-12-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:https://doi.org/10.3317/jraas.2004.040

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