Drug-Induced Hypersensitivity Syndrome Followed by Subacute Thyroiditis

Drug-Induced Hypersensitivity Syndrome Followed by Subacute Thyroiditis

Drug-induced hypersensitivity syndrome (DIHS) is a severe multiorgan system adverse drug reaction with reactivation of human herpesviruses (HHVs) such as HHV-6, HHV-7, cytomegalovirus (CMV) and Epstein-Barr virus. Various complications, including autoimmune diseases, sometimes appear during the cour...

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Bibliographic Details
Main Authors: Mika Sato, Yuki Mizuno, Kanako Matsuyama, En Shu, Hiroyuki Kanoh, Tetsuya Suwa, Mariko Seishima
Format: Article
Language:English
Published: Karger Publishers 2015-07-01
Series:Case Reports in Dermatology
Subjects:
Drug-induced hypersensitivity syndrome
Drug rash with eosinophilia and systemic symptoms
Subacute thyroiditis
Human herpesvirus 6
Cytomegalovirus
Online Access:http://www.karger.com/Article/FullText/437251
Description
Summary:Drug-induced hypersensitivity syndrome (DIHS) is a severe multiorgan system adverse drug reaction with reactivation of human herpesviruses (HHVs) such as HHV-6, HHV-7, cytomegalovirus (CMV) and Epstein-Barr virus. Various complications, including autoimmune diseases, sometimes appear during the course of DIHS. We report a case of salazosulfapyridine-induced DIHS associated with HHV-6 reactivation. Two and a half months after the onset of DIHS, subacute thyroiditis occurred, possibly associated with CMV reactivation. Prednisolone (20 mg/day) was effective for subacute thyroiditis. Long-term follow-up is needed in patients with DIHS because of the possible onset of autoimmune diseases.
ISSN:1662-6567

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