PACAP suppresses dry eye signs by stimulating tear secretion

Dry eye disease is a complex condition with limited treatments. Here the authors show that mice lacking a multi-functional peptide PACAP develop dry eye-like signs that can be topically treated with PACAP peptide that stimulates tearing in mice, suggesting a possible therapy in humans with dry eyes.

Bibliographic Details
Main Authors:	Tomoya Nakamachi, Hirokazu Ohtaki, Tamotsu Seki, Sachiko Yofu, Nobuyuki Kagami, Hitoshi Hashimoto, Norihito Shintani, Akemichi Baba, Laszlo Mark, Ingela Lanekoff, Peter Kiss, Jozsef Farkas, Dora Reglodi, Seiji Shioda
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms12034

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spelling	doaj-d48095ef948f429dba72a08d3786bfe12021-05-11T10:57:31ZengNature Publishing GroupNature Communications2041-17232016-06-017111310.1038/ncomms12034PACAP suppresses dry eye signs by stimulating tear secretionTomoya Nakamachi0Hirokazu Ohtaki1Tamotsu Seki2Sachiko Yofu3Nobuyuki Kagami4Hitoshi Hashimoto5Norihito Shintani6Akemichi Baba7Laszlo Mark8Ingela Lanekoff9Peter Kiss10Jozsef Farkas11Dora Reglodi12Seiji Shioda13Laboratory of Regulatory Biology, Graduate School of Science and Engineering, University of ToyamaDepartment of Anatomy, Showa University School of MedicineDepartment of Anatomy, Showa University School of MedicineDepartment of Anatomy, Showa University School of MedicineDepartment of Anatomy, Showa University School of MedicineLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka UniversityLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka UniversityHyogo University of Health SciencesDepartment of Analytical Biochemistry, Institute of Biochemistry and Medical Chemistry, Medical School, University of PécsDepartment of Chemistry-BMC, Uppsala UniversityDepartment of Anatomy, MTA-PTE PACAP Lendulet Research Group, Centre for Neuroscience, University of PécsDepartment of Anatomy, Showa University School of MedicineDepartment of Anatomy, MTA-PTE PACAP Lendulet Research Group, Centre for Neuroscience, University of PécsInnovative Drug Discovery, Global Research Center for Innovative Life Science, Hoshi UniversityDry eye disease is a complex condition with limited treatments. Here the authors show that mice lacking a multi-functional peptide PACAP develop dry eye-like signs that can be topically treated with PACAP peptide that stimulates tearing in mice, suggesting a possible therapy in humans with dry eyes.https://doi.org/10.1038/ncomms12034
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Tomoya Nakamachi Hirokazu Ohtaki Tamotsu Seki Sachiko Yofu Nobuyuki Kagami Hitoshi Hashimoto Norihito Shintani Akemichi Baba Laszlo Mark Ingela Lanekoff Peter Kiss Jozsef Farkas Dora Reglodi Seiji Shioda
spellingShingle	Tomoya Nakamachi Hirokazu Ohtaki Tamotsu Seki Sachiko Yofu Nobuyuki Kagami Hitoshi Hashimoto Norihito Shintani Akemichi Baba Laszlo Mark Ingela Lanekoff Peter Kiss Jozsef Farkas Dora Reglodi Seiji Shioda PACAP suppresses dry eye signs by stimulating tear secretion Nature Communications
author_facet	Tomoya Nakamachi Hirokazu Ohtaki Tamotsu Seki Sachiko Yofu Nobuyuki Kagami Hitoshi Hashimoto Norihito Shintani Akemichi Baba Laszlo Mark Ingela Lanekoff Peter Kiss Jozsef Farkas Dora Reglodi Seiji Shioda
author_sort	Tomoya Nakamachi
title	PACAP suppresses dry eye signs by stimulating tear secretion
title_short	PACAP suppresses dry eye signs by stimulating tear secretion
title_full	PACAP suppresses dry eye signs by stimulating tear secretion
title_fullStr	PACAP suppresses dry eye signs by stimulating tear secretion
title_full_unstemmed	PACAP suppresses dry eye signs by stimulating tear secretion
title_sort	pacap suppresses dry eye signs by stimulating tear secretion
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-06-01
description	Dry eye disease is a complex condition with limited treatments. Here the authors show that mice lacking a multi-functional peptide PACAP develop dry eye-like signs that can be topically treated with PACAP peptide that stimulates tearing in mice, suggesting a possible therapy in humans with dry eyes.
url	https://doi.org/10.1038/ncomms12034
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PACAP suppresses dry eye signs by stimulating tear secretion

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