PACAP suppresses dry eye signs by stimulating tear secretion
Dry eye disease is a complex condition with limited treatments. Here the authors show that mice lacking a multi-functional peptide PACAP develop dry eye-like signs that can be topically treated with PACAP peptide that stimulates tearing in mice, suggesting a possible therapy in humans with dry eyes.
Bibliographic Details
| Main Authors: |
Tomoya Nakamachi,
Hirokazu Ohtaki,
Tamotsu Seki,
Sachiko Yofu,
Nobuyuki Kagami,
Hitoshi Hashimoto,
Norihito Shintani,
Akemichi Baba,
Laszlo Mark,
Ingela Lanekoff,
Peter Kiss,
Jozsef Farkas,
Dora Reglodi,
Seiji Shioda |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2016-06-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms12034
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