Discovery and Biological Evaluation of CD147 <i>N</i>-Glycan Inhibitors: A New Direction in the Treatment of Tumor Metastasis

Discovery and Biological Evaluation of CD147 <i>N</i>-Glycan Inhibitors: A New Direction in the Treatment of Tumor Metastasis

<i>N</i>-glycosylation is instrumental to the regulation of CD147 functions, including the maturation of CD147, secretion of matrix metalloproteinases (MMPs), and promotion of tumor metastasis. Glycosylated CD147 is highly expressed in various cancer types, participates in metastasis, an...

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Bibliographic Details
Main Authors: Wenqian Li, Daojiong Wang, Yushu Ge, Lei Zhang, Jiang Wu, Dan Liu
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
CD147
<i>N</i>-linked glycosylation
inhibitors
metastasis
Online Access:https://www.mdpi.com/1420-3049/26/1/33

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